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Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases
Moreover, the dose-dependent effect of HLA-DR2 haplotypes on MS susceptibility suggests a potential link between genetic factors and disease manifestation [153]
However, excessive administration may increase the risk of side effects such as headache, dizziness, nausea, or injection site reactions
Molecular mechanisms of dietary restriction promoting health and longevity
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