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CuSO 4 -treated HepG2 cells also showed better viability, with 50% toxicity at 1.21mmol/l in HepG2 and 0.98mmol/l in HepG2 ATP7B-KO cells

As presented above, the main molecular target for the peptide is NO, particularly eNOS-derived NO, which can act on a number of target enzymes and proteins

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Appetite and Food Intake Reduction Moderate Research Cagrilintide acts on brain regions involved in hedonic appetite regulation, complementing the homeostatic appetite suppression provided by GLP-1 receptor agonists