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In further embodiments, the auris formulation or composition contains a viscosity enhancing agent or viscosity modulating agent sufficient to provide a viscosity of between about 10 and 1,000,000 centipoise, between about 100 and 1,000,000 centipoise, between about 500 and 1,000,000 centipoise, between about 750 and 1,000,000 centipoise

Chromosomes were arrested in metaphase, stained with Giemsa R66, and examined microscopically

In some embodiments, the otic formulation or composition comprises about 0.5% by weight of the cholesterol

Unlike allopurinol, which interacts with warfarin (Coumadin), febuxostat did not have this interaction when studied