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This is stress response to rapid weight loss and caloric restriction, not direct medication effect

Curcumin Reported dosage: 24.5 grams daily (but formulations vary) Curcumin is a major active constituent of turmeric, a rhizome used for millennia as a traditional culinary ingredient and in Ayurvedic medicine as a remedy for health concerns such as musculoskeletal, digestive, and skin conditions (Aggarwal 2007)

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Lastly, a post-hoc analysis of the aforementioned 26-week trial analyzed biomarkers to assessed insulin sensitivity and beta-cell function