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Faller P, Hureau C

Also, ghrelin, a hormone produced mainly in the stomach, boosts GH release through its own receptor pathway, providing a third control input

The REDEFINE 3 cardiovascular outcomes trial which will take several years to complete is not a prerequisite for initial market authorisation for obesity treatment, but its results will likely be important for subsequent label expansion and for establishing the cardiovascular benefit profile that has proven so valuable for tirzepatide and semaglutide

The triple agonist pathway offers additional levers that a single-agonist compound cannot pull