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Understanding this pharmacokinetic principle helps set realistic expectations for symptom improvement

Individual factors such as baseline gut sensitivity, concurrent medications (especially metformin, which can independently cause diarrhea), and pre-existing conditions like irritable bowel syndrome significantly influence whether diarrhea develops and its severity

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Furthermore, despite the 5 % weight loss at week nine, subjects taking inulin ate significantly less (~270 kcal less, p = 0.027) at the follow-up ad libitum meal, with no consequent rebound in food intake at the 18 week visit despite a total 7 % weight loss in the inulin group, suggesting that inulins effect on weight management is mediated via appetite modulation