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doi: 10.1016/j.tplants.2013.06.003 24 JainM.GhanashyamC.BhattacharjeeA

LDL-C: low-density lipoprotein cholesterol

The combination Qsymia (phentermine + topiramate) is a separate FDA-approved medication that pairs a low-dose stimulant with an anti-seizure drug but even Qsymia produces less weight loss than semaglutide alone (10% vs 15%)

In older adults, that can translate into weakness, falls, and loss of independence if they are not protecting muscle with protein and resistance work