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SAM is the body's primary methyl donor for hundreds of methylation reactions (DNA methylation, protein methylation, neurotransmitter synthesis, etc.)

joint involvement with pain/swelling/erythema), in the context of the patients history, with supporting evidence of elevated serum urate levels at a time other than during an acute attack Elevated serum urate levels alone are not diagnostic of gout, but may inform lifestyle changes (if relevant) and subsequent follow-up testing Treat gout flares with a NSAID, prednisone or low-dose colchicine

They are particularly valuable for individuals with dietary restrictions or absorption issues who may not receive adequate B-12 from their diet alone

Certificates of Analysis describing analytical testing and batch verification are available to support rigorous biochemical and signaling research