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This study also importantly demonstrates that metformin treatment significantly alters the metabolic profile and inflammatory secretome in rectal cancer biopsies, with minimal impact on non-cancer rectal tissue, supporting its potential as a radiosensitising agent in rectal cancer
Moreover, we observed a pattern of gene expression consistent with the response to an iron overload, such as the upregulation of HMOX1 (encoding heme oxygenase 1) 69 , SLC40A1 (encoding ferroportin), FTH1 and FTL (encoding ferritin heavy and light chains, respectively) 70 , and metallothioneins 71 (Fig
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