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236 Bacteria-derived lipopolysaccharide (which is a canonical PAMP often used to instigate reactive astrogliosis and microgliosis) act as agonists of TLR2 and 4

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An LPS-free peptide indicates that Cagrilintide has been tested to confirm the absence of lipopolysaccharides, which are bacterial endotoxins that can interfere with experimental outcomes

Activating these receptors may help reduce brain inflammation a catalyst to many neurodegenerative diseases while also encouraging the growth of new neurons in the hippocampus, the brains learning and memory region