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Homocysteine level is a more direct measure of the function of vitamin B12 and folic acid (compared to red blood cell or serum testing)

Platinum-based chemotherapeutic agents, including first-generation cisplatin, second-generation carboplatin and nedaplatin, third-generation oxaliplatin and lobaplatin, as well as novel platinum agents (e.g., ormaplatin, satraplatin), exert their antineoplastic effects primarily by targeting nuclear DNA

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For example, for some people, it may present primarily with skin issues whereas other people may have only digestive symptoms