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NICE-recommended approaches include lifestyle modification with dietary changes and physical activity, licensed medications such as semaglutide (Wegovy) or tirzepatide monotherapy, adequate protein intake (1.21.6 g/kg daily), and progressive resistance training at least twice weekly

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Abbreviations PD : Parkinson Disease CoQ10 : Coenzyme-Q10 UPDRS : Unified Parkinson Disease Rating Scale ROS : Reactive oxygen species RNS : Reactive nitrogen species SUV : Small unilamellar vesicles TEM : Transmission electron microscopy XRD : X-ray diffraction OFT : Open field test SOD : Superoxide dismutase CAT : Catalase MDA : Malondialdehyde GSH : Glutathione PC : Protein content NO : Nitric oxide DPPH : 2,2-Diphenyl-1-picrylhydrazyl AChE : Acetylcholinesterase TH : Tyrosine hydroxylase DAT : Dopamine transporter GFAP : Glial fibrillary acidic protein References See, W.Z.C., R

Interestingly, we noted upregulation of PPAR signaling pathways in hepsin / mice just 1-h post-APAP exposure (Fig