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& Collodel, G

More importantly, using human embryonic stem cell (hESC) culture models, researchers showed that these mitochondrial dysfunction signatures occur in HD-affected hESCs but not HD-affected hESCs-derived neural lineage cells, while a shift to transcriptional dysregulation and cytoskeletal abnormalities, the primary HD pathologies, appears in HD-affected differentiating hESCs along neural lineages in vitro (Monk and Connor, 2021)

The first is because it is broken down in the digestive system and liver, so only a small amount of it is absorbed intact into the bloodstream

While this sounds encouraging, we must recognize this was not a controlled trial there was no placebo group, and the patients (and doctors) knew they were receiving the peptide