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219 NAPRT negative tumors have in common that they present mutations in isocitrate dehydrogenase 1/2 (IDH)

It has been shown that VitC selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH [32], which may also explain why VitC shows to be especially promising in the treatment of pancreatic cancer, where over 90% of the cases harbour KRAS mutations [260] and MM, where RAS family genes also show the most frequent mutations [113]

We constructed natural product-gene-pathway networks for (-)-Vestitol and Salviolone on the basis of their corresponding pathways and genes