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Figure 2B focuses on direct and incretin-mediated signaling to the -cell, depicting how BefA, LPS and microbial tryptophan metabolites act on intestinal epithelial and enteroendocrine cells to modulate GIP and GLP-1 secretion and how these hormones, together with BefA, engage GIPR/GLP1R, cAMPPKA/EPAC2 and PI3K/AKT pathways to regulate -cell Ca 2+ influx, survival, proliferation and insulin granule exocytosis

The effect is more pronounced in overweight or obese individuals and when the treatment is combined with a caloric deficit and physical activity

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Per Milliliter in another study guides in the blood plasma of medical students from University of California, San Francisco, they took