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Gastric side effects (nausea, constipation), renal function, thyroid markers, and pancreatitis risk should be assessed at least quarterly

& Pardoll, D

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Clathrin-mediated endocytosis (CME) usually requires arrestin to act as a scaffolding protein to link the receptor to the 2-adaptin subunit of adapter protein 2 (AP2), which then targets the receptor to clathrin-coated pits ( via clathrin-coated pits is an arrestin-independent process for GLP-1R (Syme et al., 2006