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Table 2 Signal detection for GLP-1 RAs-associated gastrointestinal adverse events

People with depression are often characterized by a significantly lower number of microorganisms in the GI tract along with a decreased diversity of the gut microbiome [99]

The content of Fe 2+ is strictly regulated, and when its level is out of balance, excess ferrous will provide electron-promoting lipid peroxidation via Fenton reaction, resulting in an increased production of ROS and inducing ferroptosis ( c and GPX4, respectively