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By 2015, they were also approved as chronic weight management drugs after their effects on the central nervous systemsuch as appetite regulation and promoting satietyand their weight loss benefits were confirmed

An increased risk of NAFLD (Non-alcoholic fatty liver disease) is seen in obese patients, with annual burdens in the treatment of NAFLD estimated to be in the hundreds of billions for the US [10]

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Understanding how peptides interact with cellular signaling provides important context for why pathway-specific interventions like PTD-DBM represent a fundamentally different approach than conventional treatments