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As life expectancy increases nowadays, OA affects millions of people in the world and has changed to a major cause of disability and lower living standard in the elder, which also dramatically increases the burden on patients and society
De todas formas, los beneficios obtenidos en sujetos con dficit de carnitina no pueden extrapolarse a las personas sanas en donde, si bien la realizacin de un ejercicio sostenido y prolongado puede determinar una reduccin significativa de las concentraciones de carnitina muscular, el grado de esta disminucin no debera alcanzar valores superiores al 20% y por lo tanto no debieran afectar el rendimiento fsico (Brass 2004)
In addition to its role in energy metabolism with some antioxidant properties, L-acetyl-carnitine can cross the blood-brain barrier, where it modulates brain neurotransmitters, such as acetylcholine, serotonin and dopamine, and acts on neurotrophic factors by modifying the activity of the relevant genes
Fifth, we performed the main analysis restricting the study population to men with one or more prescriptions for an oral glucose-lowering drug prior to index to avoid including patients with type 1 diabetes mellitus
