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RSL3 suppresses spheroid formation and viability, and halts migration of PTC cells in vitro We postulated that the RSL3-mediated suppression of thyroid tumor cell viability is a ferroptosis pathway-dependent process, therefore, we treated K1 cells with a lethal dose of RSL3 alone and in the presence of either a ferroptosis inhibitor Fer1, or a pan caspase inhibitor, Z-VAD-FMK (ZVAD) and measured cell viability

In addition, some vitamins act as potent antioxidants, inhibiting free radical-induced damage to cell membranes and decreasing seminal ROS

Strong inhibition of the polyol pathway diverts glucose flux to protein glycation leading to rapid establishment of secondary complications in diabetes mellitus

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