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In the human skeletal muscle (pH 7.1), which lacks carnosinase-1, the degradation of carnosine by carnosinase-2 is very limited, because its optimal pH 9.5 is much greater than the intracellular pH and its V max is 30 times lower than that of carnosinase activity in the human kidneys (Lenney et al
doi: 10.3389/fendo.2021.721135 10
IGF-1 operates within a complex network of growth factors, receptors, and binding proteins that mediate cell proliferation, differentiation, and apoptosis
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