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Supplementary findings also showed higher reduction in fasting insulin levels in the semaglutide group (7% vs 26%) and higher reductions in liver function biomarkers (ALT and AST reduction of 11% vs 24% respectively) - however this analysis was performed only in a small subset of patients (n=95 in the intervention and n=45 in placebo group)

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While direct reproductive toxicity has been extensively documented, the mechanisms underlying heritable reproductive dysfunction represent an emerging frontier requiring intensive investigation ( Figure 3 )

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