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The therapy may cause other safety issues that require monitoring and/or adjustments in treatment, including: impaired tolerance to blood sugar, which may lead to diabetes progression of existing scoliosis, a side-to-side curve of the spine severe allergic reactions low function of the adrenal glands or low blood levels of the cortisol hormone low thyroid function slipped capital femoral epiphysis, a condition where the head of the thigh bone slips out of place, causing pain increased risk of cancer growth for patients with an active tumor or cancer increased blood levels of certain molecules, enzymes, and hormones pancreas inflammation

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Many patients report significant improvements in blood sugar control, reduced risk of cardiovascular complications, and in some cases, notable weight loss