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In this investigation, we initially identified oridonin as a direct covalent inhibitor of GSH, setting it apart from other drugs that disrupt ROS by targeting proteins both upstream and downstream of GSH

#diabetes #GLP1 #ozempic #obesity #HealthPolicy #weightMaintenance GLP1s have so much more benefit than just the weight-loss effect that MUST be taken into account that most physicians are not aware of: - Anti-inflammatory: inhibition of pro-inflammatory cytokines (TNF-alpha, IL1-beta, IL6), which are the pathogenesis of systemic inflammation

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Kuwabara, and Y