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GSH depletion is another problem caused by cisplatin toxicity and cell harm [28]

Penders J, Thijs C, Mommers M, Stobberingh EE, Dompeling E, Reijmerink NE, et al

Observed Heart Rate Changes: Increase of 5-10 beats per minute during treatment Peak increase around week 24, then gradual decline Persists but diminishes through week 68 Why This Happens: Sympathetic nervous system activation Increased metabolic rate from weight loss Direct effects on cardiac tissue Clinical Significance: Modest heart rate increases (5-10 bpm) don't appear harmful in clinical trials

Sterile Water for Injection, USP is a sterile, non-pyrogenic preparation of water for injection which contains no bacteriostat, antimicrobial agent or added buffer and is supplied only in single-dose containers to dilute or dissolve drugs for injection