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Comprehensive lifestyle interventions remain the cornerstone of weight maintenance and should be intensified before and after medication discontinuation

Sometimes the answer isnt a stronger biologic its addressing the metabolic inflammation feeding the fire

Nonetheless, in patients at high risk of sarcopenia, tailored management including nutritional optimization and concurrent resistance training should be considered to mitigate potential adverse consequences during pharmacologically induced weight loss [20]

IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery