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It may also reduce production of pro-inflammatory cytokines while supporting production of anti-inflammatory compounds, helping restore proper immune balance

Saikosaponin D inhibits nasal inflammation by regulating the transcription factors T-box protein expressed in T cells/GATA-3 and retinoic acid-related orphan nuclear receptor t in a murine model of allergic rhinitis

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To be specific, deletion of GPX4 in T cells resulted in loss of Tfh cells and GC responses in immunized mice, suggesting that Tfh cells are particularly susceptible to ferroptosis