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Activation of the SIRT6-AMPK signaling pathway by GLP-1RAs may therefore represent an attractive therapeutic strategy to prevent the development and progression of NAFLD and related cardiovascular diseases by modulating cholesterol metabolism

Garcia-Gutierrez, E., Narbad, A

Contributing factors include: reduced nutritional intake (proteins, essential amino acids, competition between amino acid transporters, vitamin insufficiency [riboflavin: GSSG reductase, nicotinic acid: NADPH, pyridoxine (B 6 ): SAMe pathway], mitochondrial dysfunction: ATP deficiency, down regulation SAMe synthase, oxidation of SAMe pathway enzymes, enhanced GSH utilization: conjugation reactions (toxins, drugs), and overwhelming oxidative challenge

Weight Management: It is often included in weight loss products due to its role in fat metabolism, helping individuals seeking to manage their weight effectively