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[61] first suggested O-GlcNAcylation modulated insulin sensitivity and showed that the effects of glucose-induced insulin resistance could be blocked by inhibiting GFAT using amidotransferase inhibitors such as O-diazoacetyl-L-serine (azaserine) or 6-diazo-5-oxonorleucine (DON)

Experimental work has found that KPV can suppress aspects of NF-B signaling in airway epithelial models

It would therefore be interesting to determine if the opposite approach, i.e., simultaneously inhibiting ARC AgRP/NPY neurons and activating ARC POMC neurons, additively reduces food intake and leads to weight loss in the chronic setting as this would be therapeutically relevant

The top 3 identified otologic side effects included nasopharyngitis, sinusitis, unspecified dizziness