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Economic modeling in patients with obesity and knee osteoarthritis suggests that both semaglutide and tirzepatide would generally be considered cost-effective compared with usual care, with tirzepatide offering the more favorable return on investment once willingness-to-pay thresholds exceed $57,400 per QALY ( 9 Conclusion GLP-1 receptor agonists have expanded the therapeutic discussion in obesity-related knee osteoarthritis by making substantial pharmacologic weight loss achievable for selected patients

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