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The foundational mechanism paper that established MOTS-c as a therapeutically relevant peptide is also worth citing directly: a peer-reviewed Cell Metabolism study by Lee and colleagues showing that the mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance through the AMPK pathway

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These formulations bypass the injection process entirely, which appeals to patients with needle anxiety

Lilly is one of many major pharma companies to invest in US manufacturing since the beginning of 2025