semaglutide and opioids may reduce opioid overdoses, a new study suggests GLP-1 Agent May Hold Opioid

(PubMed) Bays HE, McKenney J, Maki KC, Doyle RT, Carter RN, Stein E

In a detailed follow-up analysis of SELECT, researchers found: People got similar cardiovascular protection whether they: lost 5% of body weight, or lost very little weight (or even none) Thats a major finding because it suggests semaglutide may protect the heart through multiple pathways, such as: lowering inflammation improving blood vessel function reducing blood pressure improving cholesterol and lipid markers In SELECT, semaglutide also improved several risk indicators, including lower blood pressure and a major drop in C-reactive protein (CRP) a marker linked with inflammation and heart risk

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Lilly reported these topline results in 20252026