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The protective effects of GLP-1 RAs against cardiovascular events have been demonstrated in several studies, thus supporting their application in patients with heart failure with preserved ejection fraction and DM2 ( Taken together, GLP-1 is a major metabolic and regulatory hormone, with many potential therapeutic implications beyond glycemic control, encompassing cardiovascular protection, enhanced renal function, and the potential benefits in hepatic disease

Broader melanocortin receptor profile than selective MC1R agonists, with both peripheral pigmentation and central appetite/sexual function effects

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doi:10.1172/JCI112855 Holst JJ