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C.Lo ReV.3rdet al (2025)

Early evidence already suggests that such multiplex regimens outperform single-agent therapy where metabolic heterogeneity blunts isolated responses (81, 85) (Table 3) Future work must dissect mechanism-specific dosing ratios, develop quantitative biomarkers of combinatorial efficacy, and deliver large, stratified, randomized trials to confirm both safety and clinical relevance

Because sermorelin modulates the hypothalamic-pituitary-adrenal (HPA) axis, patients with pituitary tumors, untreated hyperthyroidism, or acute critical illness face elevated risk