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Bacteriocins exhibit the highest level of antibacterial activity against Escherichia at temperatures below 20 C, and their lowest activity at ambient temperatures (28 2 C) 191

This profibrotic effect may be reinforced by interactions with hepatic stellate cells, as in vitro co-culture experiments indicate that activated stellate cells support B-cell survival and activation through retinoic acid secretion (166) ( Figure 7D )

This effect is thought to be mediated by the activation of adenylyl cyclase, leading to the inhibition of multiple signal transduction pathways such as ERK, JNK, and NFB