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PBN applications in hemorrhagic disorders While endogenous/exogenous coagulation critically involves platelets [159], clinical platelet transfusion for acute hemorrhage, thrombocytopenia, and surgical management faces significant limitations: supply constraints, portability issues, bacterial contamination risks, specialized storage requirements ( 5-day shelf life), and functional degradation during cryopreservation/lyophilization [160,161,162,163,164,165,166]

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