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Some people with slow COMT report irritability or mood changes when taking methyl donors or COMT inhibitors

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Critically, therapeutic modulation of this pathway has demonstrated behavioral efficacy: electrical stimulation at auricular points combined with sound masking improved tinnitus-related behavioral measures (GPIAS ratios) in salicylate-induced tinnitus rats, and this effect was associated with reversal of BDNF/TrkB/CREB signaling pathway overactivation in the AC (Yang et al., 2019)

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