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However, the non-medical use of Melanotan II raises significant safety and ethical concerns

Pharmaceutical-grade retatrutide (the version used in Eli Lilly's clinical trials) is made under strict manufacturing standards with rigorous purity testing

In February, Kennedy said the FDA acted illegally in 2023 when it categorized 19 peptides as too unsafe for compounders, whose final products arent tested or approved by the FDA

Available inducers (e.g., erastin, RSL3, elesclomol) often suffer from poor pharmacokinetics, limited tumor selectivity, and narrow therapeutic windows, leading to potential off-target toxicity