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Context-dependent cytoprotection-associated profile: BPC-157-associated findings are most often reported in experimental models involving tissue injury, stress, vascular disturbance, or repair-associated endpoints rather than in basal, uninjured systems

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The outcome suggested that a transient and limited increase in gut permeability compared with the unregulated breach of the gut barrier function due to the TJ deregulation and epithelial cell apoptosis can rather lead to a dominant regulatory immune response to gut microbiota antigens and to a net anti-inflammatory effect