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Blood sugar swings in people with insulin resistance or prediabetes create a chaotic neurotransmitter environment that can manifest as mood instability, brain fog, and anxiety

doi: 10.1093/ckj/sfab078 287

The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]

In conclusion, this study systematically reveals for the first time the molecular mechanism by which PLB improves ovarian function in PCOS mice by inhibiting the YTHDF1/SLC7A5 axis, modulating m6A methylation modification, and inhibiting the ferroptosis pathway