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Recently, High-resolution MS (HRMS) has been used to discover new bioactive substances such as nutrients in herbal products and dietary supplements, to identify components of food pollutants, and to investigate the pharmacokinetics, oral bioavailability, and tissue distribution of effective ingredients in Chinese medicinals (15, 16)

Regul Toxicol Pharm

doi: 10.3389/fnut.2026.1774375 Received 23 December 2025 Revised 22 January 2026 Accepted 26 January 2026 Published 17 February 2026 Volume 13 - 2026 Edited by Abul Hossain, University of British Columbia, Canada Reviewed by Changbao Sun, Qiqihar University, China Suresh Kumar, National Institute of Biologicals, India Updates Copyright 2026 Egas-Montenegro, Echeverria-Chilla, Garca-Ulloa, Aizaga-Benalcazar and Ordoez-Araque

Butyrate could reduce the hepatotoxicity of APAP and GP through activating Nrf2-mediated antioxidant signaling [134, 135]