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Alcohol has a biphasic effect on striatal extracellular glutamate levels with low doses increasing and high doses decreasing extracellular glutamate (Moghaddam and Bolinao, 1994

DOI: 10.3390/jcm12175653 59

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As rheumatologists, we must factor this weight-efficacy relationship into our analysis of treatment responses, potentially adjusting our strategies for patients with higher body weights