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Of these, early half use it for weight management rather than a diabetes treatment

Nature 518 , 413416 (2015)

Additionally, some individuals may be partial responders to GLP-1-based therapies due to various factors that aren't fully understood, including differences in individual metabolism and hormone signaling

In research, this property is studied in cachexia models (muscle loss related to cancer, HIV, aging) where restoring a positive energy balance is a therapeutic goal (Pirrello et al., 2012)