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253 The first trial enrolled 234 participants (mean age 48 years) who were unwilling or unable to use positive airway pressure (PAP) therapy, and the second group consisted of 235 participants (mean age 52 years) who had been on consistent PAP therapy for at least three months prior to screening and were expected to continue therapy during the trial

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Additional risk factors include advancing age (due to reduced gastric acid production), excessive alcohol consumption (impairing absorption and storage), and rare genetic disorders affecting B12 transport or metabolism

FDA-approved GLP-1 medications include products manufactured by: Novo Nordisk (Wegovy, Ozempic) Eli Lilly (Zepbound, Mounjaro) These medications are dispensed through regulated pharmacy channels and supported by extensive safety and efficacy data