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The key takeaway here is that the heart rate increase is a secondary effect

Lenz M, Galanis C, Mller-Dahlhaus F, Opitz A, Wierenga CJ, Szab G, et al

12 BasavarajappaH

The National Institute on Drug Abuse (NIDA) warns that individuals recovering from opioid addiction are at risk of relapse if exposed to these opioid-acetaminophen combinations