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Key limitations of current evidence include: Relatively short follow-up periods (typically 35 years) in randomised trials, whereas pancreatic cancer may take years to develop Potential for detection bias, as patients on GLP-1 therapy may undergo more frequent medical monitoring Difficulty accounting for all confounding factors in observational studies Despite these limitations, the weight of current evidence does not support a causal link between GLP-1 receptor agonist use and pancreatic cancer development

Acids 31 , 631647 (2023)

Licensed 503A compounding pharmacies can manufacture chemically identical semaglutide and tirzepatide at substantially lower cost by sourcing bulk active pharmaceutical ingredients and eliminating manufacturer marketing expenses

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