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Ethics declarations Ethics approval and consent to participate All methods were carried out in accordance with relevant guidelines and regulations
This design offers structured opportunities to make earlier decisions when the intervention shows a significant benefit and improves efficiency in research by allowing adjustments in the trial design to be made compared with traditional, fixed-period RCTs
These products are not intended to treat, cure or prevent any disease or illness
A common laboratory dilution is 2 mL of bacteriostatic water per 10mg vial, giving a 5 mg/mL solution
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