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It constitutes the fundamental cause of cardiomyocyte death, ventricular remodeling, and heart failure [189]

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Thereafter, throughout the 40-week extension, HbA1c was stable during DPP-4 inhibition, whereas in placebo-treated patients, HbA1c increased throughout the study period, resulting in a difference in HbA1c between the groups after 52 weeks of 1.1% (11 mmol/mol) [Figure 5

10.1111/j.1365-2990.2010.01135.x 141 GabrielliM.BonazziP.ScarpelliniE.BendiaE.LauritanoE