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Sirtuin activation Sirtuins (SIRT1-7) are NAD+-dependent enzymes that regulate gene expression, mitochondrial biogenesis, inflammation, and stress responses

Clinical studies of DON co-administered with PEGylated glutaminase (PEG-PGA) suggested improved efficacy and it holds promise [115]

sales of ~$4.3B, and recently approved Zepbound (~$1.7B 1H24)