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Pinpoint pupils are a sign of opioid overdose but are not pathognomonic (e.g., pontine lesions of hemorrhagic or ischemic origins may produce similar findings)

Hypertrophy + hyperplasia Animal-model research shows IGF-1 LR3 drives both fibre growth (hypertrophy) and new fibre formation (hyperplasia) - distinct from most anabolic agents

Known for its antioxidant properties, Se also serves a role in inhibiting ferroptosis (102,110)

Cisplatin-resistant OSCC cells suppress ferroptosis through upregulation of the SLC7A11-GSH-GPX4 axis, while reactivating ferroptosis can restore cisplatin sensitivity and reverse the resistant phenotype ( inhibitor erastin promotes ferroptosis via a ROS-dependent mechanism, enhances cisplatin cytotoxicity in OSCC cells, and exhibits no overt toxicity in vivo , providing a clinically translatable approach to overcome cisplatin resistance